Discovery of Resolved Debris Disk Around HD 131835

We report the discovery of the resolved disk around HD 131835 and present the analysis and modeling of its thermal emission. HD 131835 is a ~15 Myr A2 star in the Scorpius-Centaurus OB association at a distance of 122.7 +16.2 -12.8 parsec. The extended disk has been detected to ~1.5" (200 AU) at 11.7 {\mu}m and 18.3 {\mu}m with T-ReCS on Gemini South. The disk is inclined at an angle of ~75{\deg} with the position angle of ~61{\deg}. The flux of HD 131835 system is 49.3+-7.6 mJy and 84+-45 mJy at 11.7 {\mu}m and 18.3 {\mu}m respectively. A model with three grain populations gives a satisfactory fit to both the spectral energy distribution and the images simultaneously. This best-fit model is composed of a hot continuous power-law disk and two rings. We characterized the grain temperature profile and found that the grains in all three populations are emitting at temperatures higher than blackbodies. In particular, the grains in the continuous disk are unusually warm; even when considering small graphite particles as the composition.Comment: 11 pages, 5 figures, Accepted for Publication in Ap

The Study of PPAL and its Role in the Development of Physcomitrella patens

Protein Prenylation is the addition of lipids to select proteins that play a key role during the development of plants. There are three enzymes that play a role in protein prenylation: protein farnesyltransferase (PFT), protein geranylgeranyl-transferase-I (PGGT), and Rab geranylgeranyltransferase (Rab-GGT). However, there is a protein called PPAL that has a similar alpha subunit of PFT, PGGT, and RAB-GGT but its biochemical function is unknown. Physconmitrella patens, a type of moss, was chosen to explore the role of PpPPAL in the development process. There are two copies of PPAL found in moss. PPAL1 and PPAL2. To study the role of these genes, a partial knockdown line was created where one or both alpha and beta subunit genes was reduced. An artificial microRNA was created to target the PpPPAL1 and PpPPAL2 genes and was introduced into the moss via a plasmid. Once the microRNA was inserted into the moss, the moss was grown in DMSO/ beta-estradiol medium to start the suppression of gene expression. The results showed that the knockout of PpPPAL 1 and PpPPAL 2 inhibits the growth and propagation of physconmitrella patens. They also resulted in a few gametophore contents. The result indicates that PPAL plays an important role in the developmental process in P.patents. The role of PPAL in protein prenylation of physconmitrella patens give insights into how prenylation works in humans since defects in prenylation can lead to health problemshttps://ir.library.louisville.edu/uars/1069/thumbnail.jp

Ultra-High Capacity Silicon Photonic Interconnects through Spatial Multiplexing

The market for higher data rate communication is driving the semiconductor industry to develop new techniques of writing at smaller scales, while continuing to scale bandwidth at low power consumption. The question arises of how to continue to sustain this trend. Silicon photonic (SiPh) devices offer a potential solution to the electronic interconnect bandwidth bottleneck. SiPh leverages the technology commensurate of decades of fabrication development with the unique functionality of next-generation optical interconnects. Finer fabrication techniques have allowed for manufacturing physical characteristics of waveguide structures that can support multiple modes in a single waveguide. By refining modal characteristics in photonic waveguide structures, through mode multiplexing with the asymmetric y-junction and microring resonator, higher aggregate data bandwidth is demonstrated via various combinations of spatial multiplexing, broadening applications supported by the integrated platform. The main contributions of this dissertation are summarized as follows. Experimental demonstrations of new forms of spatial multiplexing combined together exhibit feasibility of data transmission through mode-division multiplexing (MDM), mode-division and wavelength-division multiplexing (MDM-WDM), and mode-division and polarization-division multiplexing (MDM-PDM) through a C-band, Si photonic platform. Error-free operation through mode multiplexers and demultiplexers show how data can be viably scaled on multiple modes and with existing spatial domains simultaneously. This work opens up new avenues for scaling bandwidth capacity through leveraging orthogonal domains available on-chip, beyond what had previously been employed like WDM and time-division multiplexing (TDM). Furthermore, we explore expanding device channel support from two to three arms. Finding that a slight mismatch in the third arm can increase crosstalk contributions considerably, especially when increasing data rate, we explore a methodical way to design the asymmetric y-junction device by considering its angles and multiplexer/demultiplexer arm width. By taking into consideration device fabrication variations, we turn towards optimizing device performance post-fabrication. Through ModePROP simulations, optimizing device performance dynamically post-fabrication is analyzed, through either electro-optical or thermo-optical means. By biasing the arm introducing the slight spectral offset, we can quantifiably improve device performance. Scaling bandwidth is experimentally demonstrated through the device at 3 modes, 2 wavelengths, and 40 Gb/s data rate for 240 Gb/s aggregate bandwidth, with the potential to reduce power penalty per the device optimization process we described. A main motivation for this on-chip spatial multiplexing is the need to reduce costs. As the laser source serves as the greatest power consumer in an optical system, mode-division multiplexing and other forms of spatial multiplexing can be implemented to push its potentially prohibitive cost metrics down. While the device introduces loss, through imperfect mode isolation, as device fabrication improves, tolerance can increase as well. Meanwhile, the rate that laser power consumption increases as supported wavelengths scales is shown to be much faster than the loss introduced by scaling on-chip bandwidth multi-modally. Future generations of ultra-high capacity devices through spatial multiplexing is explored. Already various systems can be implemented multimodally, with the design features serving as useful for other components. Central to photonic network-on-chips, a multimodal switch fabric, composed of microring resonators, is demonstrated to have error-free operation of 1x2 switching of 10 Gb/s data. These contributions aim to scale bandwidth to ultra-high capacity, while ameliorating any imperfect design, through multiple routes conjoined with on-chip spatial multiplexing, and they constitute the bulk of this dissertation. For the latter part, we turn to the issue of integrating a photonic device for dynamic power reallocation in a system. Specifically, we utilize a 4x4 nonblocking switch fabric composed of Mach-Zehnder interferometers that switch both electro-optically and thermo-optically at ns and μs rates respectively. In order to demonstrate an intelligent platform capable of dynamically multicasting data and reallocating power as needed by the system, we must first initialize the switch fabric to control with an electronic interface. A dithering mechanism, whereby exact cross, bar, and sub-percentage states are enforced through the device, is described here. Such a method could be employed for actuating the device table of bias values to states automatically. We then employ a dynamic power reallocation algorithm through a data acquisition unit, showing real-time channel recovery for channels experiencing power loss by diverting power from paths that could tolerate it. The data that is being multicast through the system is experimentally shown to be error-free at 40 Gb/s data rate, when transmitting from one to three clients and going from automatic bar/cross states to equalized power distribution. For the last portion of this topic, the switch fabric was inserted into a high-performance computing system. In order to run benchmarks at 10 Gb/s data ontop of the switch fabric, a newer model of the control plane was implemented to toggle states according to the command issued by the server. Such a programmable mechanism will prove necessary in future implementations of optical subsystems embedded inside larger systems, like data centers. Beyond the specific control plane demonstrated, the idea of an intelligent photonic layer can be applied to alleviate many kinds of optical channel abnormalities or accommodate for switching based on different patterns in data transmission. Besides spatial-multiplexing, expanding on-chip bandwidth can be accomplished by extension of the wavelength detection regime to a longer regime. Experimental demonstration of photodetection at 1.9 μm is shown with Si+-doped Si photodetectors at 1 Gb/s data operation featuring responsivities of .03 AW−1 at 5 V bias. The same way of processing these Si ribbed waveguide photodetectors can garner even longer wavelength operation at 2.2 μm wavelength. Finally, the experimental demonstration of a coherent perfect absorption Si modulator is exhibited, showing a viable extinction ratio of 24.5 dB. Using this coherent perfect absorption mechanism to demodulate signals, there is the added benefit of differential reception. Currently, an automated process for data collection is employed at a faster time scale than instabilities present in fibers in the setup with future implementations eliminating the off-chip phase modulator for greater signal stability. The field of SiPh has developed to a stage where specific application domains can take off and compete according to industrial-level standards. The work in this dissertation contributes to experimental demonstration of a newly developing area of mode-division multiplexing for substantially increasing bandwidth on-chip. While implementing the discussed photonic devices in dynamic systems, various attributes of integrated photonics are leveraged with existing electronic technologies. Future generations of computing systems should then be designed by implementing both system and device level considerations

Superficial papular neuroma: Case series of a new entity

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138273/1/cup12981.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138273/2/cup12981_am.pd

Investigation of discrepancies in satellite rainfall estimates over Ethiopia

Tropical Applications of Meteorology Using Satellite and Ground-Based Observations (TAMSAT) rainfall estimates are used extensively across Africa for operational rainfall monitoring and food security applications; thus, regional evaluations of TAMSAT are essential to ensure its reliability. This study assesses the performance of TAMSAT rainfall estimates, along with the African Rainfall Climatology (ARC), version 2; the Tropical Rainfall Measuring Mission (TRMM) 3B42 product; and the Climate Prediction Center morphing technique (CMORPH), against a dense rain gauge network over a mountainous region of Ethiopia. Overall, TAMSAT exhibits good skill in detecting rainy events but underestimates rainfall amount, while ARC underestimates both rainfall amount and rainy event frequency. Meanwhile, TRMM consistently performs best in detecting rainy events and capturing the mean rainfall and seasonal variability, while CMORPH tends to overdetect rainy events. Moreover, the mean difference in daily rainfall between the products and rain gauges shows increasing underestimation with increasing elevation. However, the distribution in satellite–gauge differences demon- strates that although 75% of retrievals underestimate rainfall, up to 25% overestimate rainfall over all eleva- tions. Case studies using high-resolution simulations suggest underestimation in the satellite algorithms is likely due to shallow convection with warm cloud-top temperatures in addition to beam-filling effects in microwave- based retrievals from localized convective cells. The overestimation by IR-based algorithms is attributed to nonraining cirrus with cold cloud-top temperatures. These results stress the importance of understanding re- gional precipitation systems causing uncertainties in satellite rainfall estimates with a view toward using this knowledge to improve rainfall algorithms

A Phase II Basket Trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609) in Patients with Nonpancreatic Neuroendocrine Tumors.

PurposeImmune checkpoint blockade has improved outcomes across tumor types; little is known about the efficacy of these agents in rare tumors. We report the results of the (nonpancreatic) neuroendocrine neoplasm cohort of SWOG S1609 dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART).Patients and methodsWe performed a prospective, open-label, multicenter phase II clinical trial of ipilimumab plus nivolumab across multiple rare tumor cohorts, with the (nonpancreatic) neuroendocrine cohort reported here. Response assessment by grade was not prespecified. The primary endpoint was overall response rate [ORR; RECIST v1.1; complete response (CR) and partial response (PR)]; secondary endpoints included progression-free survival (PFS), overall survival (OS), stable disease >6 months, and toxicity.ResultsThirty-two eligible patients received therapy; 18 (56%) had high-grade disease. Most common primary sites were gastrointestinal (47%; N = 15) and lung (19%; N = 6). The overall ORR was 25% [95% confidence interval (CI) 13-64%; CR, 3%, N = 1; PR, 22%, N = 7]. Patients with high-grade neuroendocrine carcinoma had an ORR of 44% (8/18 patients) versus 0% in low/intermediate grade tumors (0/14 patients; P = 0.004). The 6-month PFS was 31% (95% CI, 19%-52%); median OS was 11 months (95% CI, 6-∞). The most common toxicities were hypothyroidism (31%), fatigue (28%), and nausea (28%), with alanine aminotransferase elevation (9%) as the most common grade 3/4 immune-related adverse event, and no grade 5 events.ConclusionsIpilimumab plus nivolumab demonstrated a 44% ORR in patients with nonpancreatic high-grade neuroendocrine carcinoma, with 0% ORR in low/intermediate grade disease